A phase 1 study of the BCL2-targeted deoxyribonucleic acid inhibitor (DNAi) PNT2258 in patients with advanced solid tumors

作者: Anthony W. Tolcher , Wendi V. Rodrigueza , Drew W. Rasco , Amita Patnaik , Kyriakos P. Papadopoulos

DOI: 10.1007/S00280-013-2361-0

关键词:

摘要: Purpose Maximum tolerated dose, safety, pharmacokinetics, and pharmacodynamics were assessed in this phase 1 study of PNT2258, a BCL-2-targeted liposomal formulation 24-base DNA oligonucleotide called PNT100.

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