Clinical experiences with systemically administered siRNA-based therapeutics in cancer
作者： Jonathan E. Zuckerman , Mark E. Davis
DOI: 10.1038/NRD4685
关键词:
摘要: … actively escape the endocytic pathway and release the siRNA into the cytoplasm (step 6). The … Additionally, there have not been any reports of tachyphylaxis-like responses to siRNA …
core.ac.uk
nature.com
sci-hub.se 
researchgate.net 参考文章(94)
Shao-Hua Chen, Getu Zhaori, Potential clinical applications of siRNA technique: benefits and limitations. European Journal of Clinical Investigation. ,vol. 41, pp. 221- 232 ,(2011) , 10.1111/J.1365-2362.2010.02400.X
Talia Golan, Elina Zorde Khvalevsky, Ayala Hubert, Rachel Malka Gabai, Naama Hen, Amiel Segal, Abraham Domb, Gil Harari, Eliel Ben David, Stephen Raskin, Yuri Goldes, Eran Goldin, Rami Eliakim, Maor Lahav, Yael Kopleman, Alain Dancour, Amotz Shemi, Eithan Galun, RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients Oncotarget. ,vol. 6, pp. 24560- 24570 ,(2015) , 10.18632/ONCOTARGET.4183
M. I. Koukourakis, S. Koukouraki, A. Giatromanolaki, S. C. Archimandritis, J. Skarlatos, K. Beroukas, J. G. Bizakis, G. Retalis, N. Karkavitsas, E. S. Helidonis, Liposomal Doxorubicin and Conventionally Fractionated Radiotherapy in the Treatment of Locally Advanced Non–Small-Cell Lung Cancer and Head and Neck Cancer Journal of Clinical Oncology. ,vol. 17, pp. 3512- 3521 ,(1999) , 10.1200/JCO.1999.17.11.3512
Kathryn A. Whitehead, Robert Langer, Daniel G. Anderson, Knocking down barriers: advances in siRNA delivery Nature Reviews Drug Discovery. ,vol. 8, pp. 129- 138 ,(2009) , 10.1038/NRD2742
Elizabeth Pennisi, The CRISPR Craze Science. ,vol. 341, pp. 833- 836 ,(2013) , 10.1126/SCIENCE.341.6148.833
Sreenath V. Sharma, Daphne W. Bell, Jeffrey Settleman, Daniel A. Haber, Epidermal growth factor receptor mutations in lung cancer Nature Reviews Cancer. ,vol. 7, pp. 169- 181 ,(2007) , 10.1038/NRC2088
Dirk Grimm, Konrad L. Streetz, Catherine L. Jopling, Theresa A. Storm, Kusum Pandey, Corrine R. Davis, Patricia Marion, Felix Salazar, Mark A. Kay, Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature. ,vol. 441, pp. 537- 541 ,(2006) , 10.1038/NATURE04791
Robby A. Petros, Joseph M. DeSimone, Strategies in the design of nanoparticles for therapeutic applications Nature Reviews Drug Discovery. ,vol. 9, pp. 615- 627 ,(2010) , 10.1038/NRD2591
Vincent J. Venditto, Francis C. Szoka, Cancer nanomedicines: so many papers and so few drugs! Advanced Drug Delivery Reviews. ,vol. 65, pp. 80- 88 ,(2013) , 10.1016/J.ADDR.2012.09.038
Anthony W. Tolcher, Wendi V. Rodrigueza, Drew W. Rasco, Amita Patnaik, Kyriakos P. Papadopoulos, Alex Amaya, Timothy D. Moore, Shari K. Gaylor, Charles L. Bisgaier, Mina P. Sooch, Michael J. Woolliscroft, Richard A. Messmann, A phase 1 study of the BCL2-targeted deoxyribonucleic acid inhibitor (DNAi) PNT2258 in patients with advanced solid tumors Cancer Chemotherapy and Pharmacology. ,vol. 73, pp. 363- 371 ,(2014) , 10.1007/S00280-013-2361-0