Effect of contrast agent dosage on longitudinal relaxation time, signal and apparent tumor volume in glioblastoma at 9.4 T

摘要: Abstract Introduction Glioblastoma multiforme is the most frequent innate brain tumor and still yields an unfavorable prognosis of 15 months survival after diagnosis. Animal models play important role in investigation therapeutic strategies tumors. Thereby, MRI substantial to individual follow-up examination for response. Contrast agent dosage at 1.5 3 T has been thoroughly tested, while there hardly any data 9.4 T. Therefore, aim this study was find optimal contrast 9.4 T T1 relaxation time apparent volume animal model. Material methods Six animals with a U-87 glioblastoma were part study. Scans performed on MRI. The protocol contained standard T1w sequence, which employed volumetry signal intensity measurement single, double triple injections T2w sequence edema. From map, times area measured. Histologic size measurements also two animals. Results mean increased significantly each additional injection, mainly due increase hyperintense rim. Volumetry based resulted higher than volumetry, whereas approached increasing dosage. Histology revealed that corresponded hypointense center In contrast, decrease occurred Conclusion Increasing led volume. High-dose MRI, however, overestimated determined by histology. it can be concluded sufficient visualize core Measurement depicts edema, diffusion or accumulation both. Tumor visualized without need agent.