4Endocrinology of the hypothalamic-pituitary-testicular axis with particular reference to the hormonal control of spermatogenesis
作者： Alvin M. Matsumoto , William J. Bremner
DOI: 10.1016/S0950-351X(87)80053-8
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摘要: The normal physiology of the hypothalamic-pituitary-testicular axis in man is reviewed. According to current concepts, LH plays an important role initiation and maintenance spermatogenesis by stimulating Leydig cell production high concentrations T within testes. FSH thought be spermatid maturation (spermiogenesis) during stimulation Sertoli cells. Studies selective gonadotrophin replacement experimentally-induced hypogonadotrophic hypogonadal men demonstrate that qualitatively sperm can achieved either or alone, but both are necessary maintain quantitatively spermatogenesis. spontaneously-occurring suggest requirement for activity stimulate greatest at time puberty. postpubertal with acquired hypogonadism after its often alone.
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