Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging.

摘要: A novel PAMAM dendrimer-based nanoprobe for dual magnetic resonance and fluorescence imaging modalities was synthesized. Fluorescence studies revealed that Gd(III) complexation to the probe has no effect on quantum yield; however, increases in dye content resulted partial quenching. The potential of new nanoprobe, G6-(Cy5.5)(1.25)(1B4M-Gd)(145), as a modality agent demonstrated vivo by efficient visualization sentinel lymph nodes mice both MRI modalities.