Clinical efficacy of stem cell mediated osteogenesis and bioceramics for bone tissue engineering.

摘要: Lower back pain is a common disorder that often requires bony spinal fusion for long-term relief. Current arthrodesis procedures use bone grafts from autogenous bone, allogenic backed or synthetic materials. Autogenous can result in donor site morbidity and at the site, while materials have variable effectiveness. Given these limitations, researchers focused on new treatments will allow safe successful repair regeneration. Mesenchymal stem cells (MSCs) received attention their ability to differentiate into osteoblasts, synthesize extracellular matrix regulate mineralization. Successful regeneration three elements: MSCs serve as osteoblastic progenitors, osteoinductive growth factors pathways promote development differentiation of well an osteoconductive scaffold allows formation vascular network. Future should strive combine mesenchymal cells, cell-seeded scaffolds gene therapy optimize efficiency safety tissue