Intestinal epithelial barrier and mucosal immunity
作者： L Alexopoulou , D Kontoyiannis
DOI: 10.1007/S00018-005-5038-Y
关键词:
摘要: Both innate immunity and mucosal surfaces provide the first line of defence against mucosal infections. Innate immunity is a universal and evolutionarily conserved form of host defence that senses microbial organisms. Recent advances in the field of immunology are due mainly to the discovery of the role of Toll-like receptors (TLRs), which recognize conserved microbial molecules. TLR stimulation induces specific patterns of gene expression that lead to the shaping of innate and adaptive immunity. Since mucosal tissues are colonized by …
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