Secondary metabolites resulting from degradation of PR toxin by Penicillium roqueforti.
作者： S C Chang , K L Lu , S F Yeh
DOI: 10.1128/AEM.59.4.981-986.1993
关键词:
摘要: PR toxin is a secondary metabolite of the fungus Penicillium roqueforti. It lethal to rats, mice, and cats. Usually, amount in culture medium decreases from its maximum on day 15 zero within 3 4 days. We found that two were metabolites produced this while production was decreasing. isolated purified compounds pure colorless crystalline form. On basis elemental analysis mass, 1H 13C nuclear magnetic resonance, infrared, UV spectroscopies, identified as PR-imine (C17H21O5N) PR-amide (C17H21O6N). The structures both (C17H20O6) closely related, peak appeared earlier than those PR-amide. Moreover, transformed when incubated with given day. Thus, we propose degraded into P.
sci-hub.st 参考文章(14)
S. Moreau, A. Masset, J. Biguet, Resolution of Penicillium roqueforti toxin and eremofortins A, B, and C by high-performance liquid chromatography. Applied and Environmental Microbiology. ,vol. 37, pp. 1059- 1062 ,(1979) , 10.1128/AEM.37.6.1059-1062.1979
S C Chang, Y H Wei, D L Wei, Y Y Chen, S C Jong, Factors affecting the production of eremofortin C and PR toxin in Penicillium roqueforti. Applied and Environmental Microbiology. ,vol. 57, pp. 2581- 2585 ,(1991) , 10.1128/AEM.57.9.2581-2585.1991
Shenq-Chyi Chang, Yau-Huei Wei, Mei-Ling Liu, Ru-Dong Wei, Isolation and Some Properties of the Enzyme That Transforms Eremofortin C to PR Toxin Applied and Environmental Microbiology. ,vol. 49, pp. 1455- 1460 ,(1985) , 10.1128/AEM.49.6.1455-1460.1985
Ru-Dong Wei, Paul E. Still, E. B. Smalley, H. K. Schnoes, F. M. Strong, Isolation and Partial Characterization of a Mycotoxin from Penicillium roqueforti Applied Microbiology. ,vol. 25, pp. 111- 114 ,(1973) , 10.1128/AM.25.1.111-114.1973
S. Moreau, A. Lablache-Combier, J. Biguet, Production of Eremofortins A, B, and C Relative to Formation of PR Toxin by Penicillium roqueforti Applied and Environmental Microbiology. ,vol. 39, pp. 770- 776 ,(1980) , 10.1128/AEM.39.4.770-776.1980
Yau-Huei Wei, Wang-Hsien Ding, Ru-Dong Wei, Biochemical effects of PR toxin on rat liver mitochondrial respiration and oxidative phosphorylation Archives of Biochemistry and Biophysics. ,vol. 230, pp. 400- 411 ,(1984) , 10.1016/0003-9861(84)90420-X
Kwei-Perng Hsieh, Sue Yu, Yau-Huei Wei, Chieh-Fu Chen, Ru-Dong Wei, Inhibitory effect in vitro of PR toxin, a mycotoxin from Penicillium roqueforti, on the mitochondrial HCO3−-ATPase of the rat brain, heart and kidney Toxicon. ,vol. 24, pp. 153- 160 ,(1986) , 10.1016/0041-0101(86)90117-0
Shu-Chen Fang, Ru-Dong Wei, Yan-Hwa Wu Lee, The effects of Penicillium roqueforti toxin on the activity of rat hepatic DNA polymerases Toxicology. ,vol. 33, pp. 43- 57 ,(1984) , 10.1016/0300-483X(84)90015-5
Monique Cacan, Serge Moreau, Roger Tailliez, In vitro metabolism of penicillium roqueforti toxin (PRT) and a structurally related compound, eremofortin A, by rat liver. Toxicology. ,vol. 8, pp. 205- 212 ,(1977) , 10.1016/0300-483X(77)90009-9
Ru-Dong Wei, Tong-Man Ong, Wen-Zong Whong, Domenico Frezza, Giorgio Bronzetti, Errol Zeiger, Genetic effects of PR toxin in eukaryotic microorganisms. Environmental Mutagenesis. ,vol. 1, pp. 45- 53 ,(1979) , 10.1002/EM.2860010111