Simulated embryonic and fetal cellular dynamics inside structured biomaterials

摘要: Abstract In conventional tissue engineering and regenerative medicine, there is frequent modeling simulation of adult repair regeneration. However, this neglects the processes in developmental origins tissues organs, between 8 28 weeks early life, which are driven by cellular harnessing physical mechanical force fields. The learning from development process embryo fetus promises faster, facile replacements with accurate anatomical complexity. This can be achieved via replication five essential embryonic fetal cell dynamic operations: invagination, E-M M-E transitions, condensation fusions. Moreover, recent evolution structured biomaterials possessing actuating elements, it feasible to manufacture material systems that impose variable constraints on functions generate realistic patterns. review, we explain lessons learned nature fields exerted group operations during embryogenesis how these form simple anatomic structures such as, sheets condensates. Then, highlight some materials bioengineering simulations events embryology produce products prospects for human therapy. inspired has been enhanced microfluidic engineering, 3D printing, encapsulation techniques, self-organization, self-templating chemistry, fashioned build developmentally significant biomaterial based systems.