The T-1237C polymorphism of the toll-like receptor-9 gene is associated with chronic kidney disease in a Han Chinese population

摘要: Chronic kidney disease (CKD) is increasingly recognized as a global public health problem. As inflammatory processes and genetic factors are involved in the pathogenesis of CKD, we have investigated potential contribution Toll-like receptor (TLR) gene polymorphisms CKD. In case-control association study, 149 CKD patients 429 healthy controls were genotyped by real-time polymerase chain reaction. defined damage (albuminuria, proteinuria or hematuria) glomerular filtration rate < 60 ml/min/1.73 m2 for 3 months more. Single nucleotide (SNPs) at TLR-2 G2408A, TLR-4 A12874G C13174T, TLR-9 T-1237C, T-1486C, G1635A assessed, linkage disequilibrium calculations haplotype analysis undertaken. The functions been documented to recognize viral bacterial CpG DNA sequences, whereas detects microbe-derived peptidoglycan lipopeptides binds lipopolysaccharides. SNPs within TLR genes may influence promoter activity, mRNA conformation subcellular localization, and/or protein structure function. Our results show that only T-1237C demonstrate an with (p = 0.002 p 0.04, respectively). TCA was associated lower risk TTA higher Han Chinese population, those who carry C A alleles appear be more susceptible development