Association of Toll-Like Receptor 3 and Toll-Like Receptor 9 Single Nucleotide Polymorphisms with Hepatitis C Virus Infection and Hepatic Fibrosis in Egyptian Patients.
作者： Rania A. Zayed , Dalia Omran , Doha A. Mokhtar , Zinab Zakaria , Sameera Ezzat
关键词:
摘要: Toll-like receptors (TLRs) are recognized as fundamental contributors to the immune system function against infections. Hepatitis C virus (HCV) infection represents a global health problem especially in Egypt having highest HCV prevalence worldwide where is continuing epidemic. The aim of present study was investigate possible association between genetic variation TLR-3 and TLR-9 hepatic fibrosis chronic HCV-positive Egyptian patients. included 100 naive patients age- sex-matched healthy controls. Genotyping (_7 C/A [rs3775296]), (c.1377C/T [rs3775290]) (1237T/C [rs5743836]) were done by polymerase chain reaction restriction fragment length polymorphism technique. Frequency polymorphic genotypes C/A), (c.1377C/T) (1237T/C) not significantly different studied controls with P values 0.121, 0.112, 0.683, respectively. c.1377 T-allele associated advanced stage (P = 0.003).
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