Insulin resistance and hyperinsulinemia in patients with chronic congestive heart failure

摘要: Abstract Congestive heart failure is a condition associated with increased plasma norepinephrine levels. Moreover, has been recently demonstrated to affect glucose homeostasis by decreasing insulin sensitivity. In the present study, eight patients suffering from chronic congestive and 10 healthy age- body mass index-matched subjected were submitted both an oral tolerance test (OGTT; 75 g) euglycemic hyperinsulinemic clamp. During 360 minutes of clamp, was infused at three different rates (25, 50, 100 mU/kg/h), while d - 3 H infusion allowed determination turnover. basal conditions, versus controls had similar (5.2 ± 0.1 v 4.9 0.2 mmol/L, P = NS), but higher (125.7 9.2 35.7 3.3 pmol/L, 1.47 0.22 nmol/L, 792 88 μ mol/L, r .65,