Comprehensive Criteria for Assessing Therapy-Induced Toxicity

作者: Jaffer A. Ajani , Susan R. Welch , Martin N. Raber , William S. Fields , Irwin H. Krakoff

DOI: 10.3109/07357909009017560

关键词:

摘要: Methods of assessing and reporting toxic reactions induced by therapy, particularly chemotherapy, need improvements. Accurate reliable therapy-induced toxicity will be necessary for quality clinical research including drug development implementation complex multimodality treatments, currently, however, the extent vary widely. Whereas standard widely accepted criteria have been established therapeutic response, no such exist toxicity. We developed comprehensive reliably reactions. reduced degree subjectivity in assigning grades using primarily objective methods. An attempt has made to standardize "morbidity impact" each grade irrespective organ system involved.

参考文章(25)
M L Sherman, D R Spriggs, K A Arthur, K Imamura, E Frei, D W Kufe, Recombinant human tumor necrosis factor administered as a five-day continuous infusion in cancer patients: phase I toxicity and effects on lipid metabolism. Journal of Clinical Oncology. ,vol. 6, pp. 344- 350 ,(1988) , 10.1200/JCO.1988.6.2.344
R.L. Nelson, P.J. Creaven, M.H. Cohen, B.E. Fossieck, Phase I clinical trial of a 3-day divided dose schedule of ifosfamide (NSC 109724) European Journal of Cancer. ,vol. 12, pp. 195- 198 ,(1976) , 10.1016/0014-2964(76)90241-3
SEWA S. LEGHA, Reduction of Doxorubicin Cardiotoxicity by Prolonged Continuous Intravenous Infusion Annals of Internal Medicine. ,vol. 96, pp. 133- 139 ,(1982) , 10.7326/0003-4819-96-2-133
Charles G. Zubrod, Marvin Schneiderman, Emil Frei, Clyde Brindley, G. Lennard Gold, Bruce Shnider, Raul Oviedo, John Gorman, Ralph Jones, Ulfar Jonsson, Jack Colsky, Thomas Chalmers, Bruce Ferguson, Margarida Dederick, James Holland, Oleg Selawry, William Regelson, Louis Lasagna, Albert H. Owens, Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide Journal of Chronic Diseases. ,vol. 11, pp. 7- 33 ,(1960) , 10.1016/0021-9681(60)90137-5
Richard A. Gams, George A. Omura, Enrique Velez-Garcia, Robert Kellermeyer, Marilyn Raney, Alfred A. Bartolucci, Alternating sequential combination chemotherapy in the management of advanced Hodgkin's disease. A Southeastern Cancer Study Group trial. Cancer. ,vol. 58, pp. 1963- 1968 ,(1986) , 10.1002/1097-0142(19861101)58:9<1963::AID-CNCR2820580902>3.0.CO;2-P
JafferA. Ajani, JackS. Faintuch, RoxannK. McClure, Bernard Levin, BruceM. Boman, IrwinH. Krakoff, Phase II study of spirogermanium in patients with advanced colorectal carcinoma Investigational New Drugs. ,vol. 4, pp. 383- 385 ,(1986) , 10.1007/BF00173512
Giorgio Cocconi, Maurizio Tonato, Francesco di Costanzo, Giancarlo Bisagni, Virginio Belsanti, Franco Buzzi, Guido Ceci, Platinum and etoposide in chemotherapy refractory metastatic breast cancer. A phase II trial of the Italian oncology group for clinical research (G.O.I.R.C.) European Journal of Cancer and Clinical Oncology. ,vol. 22, pp. 761- 764 ,(1986) , 10.1016/0277-5379(86)90360-3
JafferA. Ajani, JamesL. Abbruzzese, JackS. Faintuch, Roxann Blackburn, Bernard Levin, BruceM. Boman, Phase II study of fludarabine phosphate in patients with advanced colorectal carcinoma. Investigational New Drugs. ,vol. 6, pp. 47- 50 ,(1988) , 10.1007/BF00170780
Robert E. Wittes, Alan Yagoda, Olga Silvay, Gordon B. Magill, Willet Whitmore, Irwin H. Krakoff, Robert B. Golbey, Chemotherapy of germ cell tumors of the testis. I. Induction of remissions with vinblastine, actinomycin D, and bleomycin Cancer. ,vol. 37, pp. 637- 645 ,(1976) , 10.1002/1097-0142(197602)37:2<637::AID-CNCR2820370205>3.0.CO;2-M
Martin M. Oken, Richard H. Creech, Douglass C. Tormey, John Horton, Thomas E. Davis, Eleanor T. McFadden, Paul P. Carbone, Toxicity and response criteria of the Eastern Cooperative Oncology Group American Journal of Clinical Oncology. ,vol. 5, pp. 649- 655 ,(1982) , 10.1097/00000421-198212000-00014