Conjunctiva-associated lymphoid tissue in the human eye.

摘要: Purpose Mucosa-associated lymphoid tissue (MALT) represents a part of the immune system located at mucosal surfaces. Its presence in human eye is point question current study. occurrence, components, topography, and probable functional significance conjunctiva lacrimal drainage were investigated. Methods Fifty-three complete conjunctival sacs obtained from cadaveric eyes, prepared as flat wholemounts, stained, optically cleared, observed total thickness, sectioned for light microscopic histology, immunohistochemistry, electron microscopy. Eight adhering canaliculi accordingly. Results Lymphoid was mainly palpebral conjunctiva, more pronounced upper than lower lid. It occurred different forms: 1) In all specimens, diffuse lymphocytes plasma cells, most which IgA positive, formed thin layer lamina propria. The overlying epithelium produced secretory component. 2) approximately three fifths sacs, organized follicular accumulations embedded this layer. They had lenticular shape, composed B lymphocytes, apically covered by lymphoepithelium. 3) Both types could be associated with crypts. similar characteristics, including secondary follicles, also inside system. High endothelial venules present tissue. Conclusions Human show an (suggesting term conjunctiva-associated [CALT]) that contains components necessary response. Expression immunoglobulins component indicates belongs to