CD28 down-regulation on CD4 T cells is a marker for graft dysfunction in lung transplant recipients.
作者： Sean M. Studer , M. Patricia George , Xuehai Zhu , Yifang Song , Vincent G. Valentine
DOI: 10.1164/RCCM.200701-013OC
关键词:
摘要: Rationale: Repeated antigen-driven proliferations cause CD28 on T cells to down-regulate. We hypothesized that alloantigen-induced could down-regulation in lung transplant recipients.Objectives: To ascertain if CD4 associated with manifestations of allograft dysfunction recipients.Methods: Peripheral blood from 65 recipients were analyzed by flow cytometry, cytokine multiplex and proliferative assays, correlated clinical events.Measurements Main Results: Findings was present less than 90% total predominantly seen among the bronchiolitis obliterans syndrome (specificity = 88%). Perforin granzyme B produced >50% CD4+CD28null cells, but 6% autologous CD4+CD28+ (P < 0.006). also had increased productions proinflammatory cytokines, frequently expressed regulatory T-cell marker FoxP3 (2.1 ± 1.3%...
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