Resisting resistance: is there a solution for malaria?
作者： Bianca K. Verlinden , Abraham Louw , Lyn-Marié Birkholtz
DOI: 10.1517/17460441.2016.1154037
关键词:
摘要: ABSTRACTIntroduction: Currently, widely used antimalarial drugs have a limited clinical lifespan due to parasite resistance development. With continuously rising, drug discovery requires strategies decrease the time of delivering new while simultaneously increasing drug’s therapeutic lifespan. Lessons learnt from various chemotherapeutic studies in fields antibiotic and cancer research offer potentially useful that can be applied discovery.Areas covered: In this review authors discuss current circumvent malaria alternatives could employed.Expert opinion: Scientists been ‘beating back’ with novel for past 49 years but constant rise is forcing community explore alternative strategies. Avant-garde anti-resistance may assist our endeavors t...
up.ac.za
sci-hub.se 参考文章(106)
Erika L. Flannery, David A. Fidock, Elizabeth A. Winzeler, Using genetic methods to define the targets of compounds with antimalarial activity Journal of Medicinal Chemistry. ,vol. 56, pp. 7761- 7771 ,(2013) , 10.1021/JM400325J
Peter G. Kremsner, Ayôla Akim Adegnika, Saadou Issifou, Bertrand Lell, Selidji Todagbe Agnandji, Emmanuel B. Bache, Benjamin Gottlieb Mordmüller, José Francisco Fernandes, Abraham Sunday Alabi, Béatrice Peggy Abossolo, Marguerite M. Loembe, Anita Lumeka Kabwende, Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. The Lancet. ,vol. 386, pp. 31- 45 ,(2015) , 10.15496/PUBLIKATION-6508
Aislyn D W Boran, Ravi Iyengar, Systems approaches to polypharmacology and drug discovery. Current Opinion in Drug Discovery & Development. ,vol. 13, pp. 297- 309 ,(2010)
Samir Bhatt, DJ Weiss, E Cameron, D Bisanzio, B Mappin, U Dalrymple, KE Battle, CL Moyes, A Henry, PA Eckhoff, EA Wenger, O Briët, MA Penny, TA Smith, A Bennett, J Yukich, TP Eisele, JT Griffin, CA Fergus, M Lynch, F Lindgren, JM Cohen, CLJ Murray, DL Smith, SI Hay, RE Cibulskis, PW Gething, None, The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015 Nature. ,vol. 526, pp. 207- 211 ,(2015) , 10.1038/NATURE15535
Timothy N. C. Wells, Rob Hooft van Huijsduijnen, Wesley C. Van Voorhis, Malaria medicines: a glass half full? Nature Reviews Drug Discovery. ,vol. 14, pp. 424- 442 ,(2015) , 10.1038/NRD4573
Nigel J. Pyne, Melissa McNaughton, Stephanie Boomkamp, Neil MacRitchie, Cecilia Evangelisti, Alberto M. Martelli, Hui-Rong Jiang, Satvir Ubhi, Susan Pyne, Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation Advances in Biological Regulation. ,vol. 60, pp. 151- 159 ,(2016) , 10.1016/J.JBIOR.2015.09.001
Steven J. Burgess, Jane X. Kelly, Shawheen Shomloo, Sergio Wittlin, Reto Brun, Katherine Liebmann, David H. Peyton, Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds. Journal of Medicinal Chemistry. ,vol. 53, pp. 6477- 6489 ,(2010) , 10.1021/JM1006484
Bianca K. Verlinden, Jandeli Niemand, Janette Snyman, Shiv K. Sharma, Ross J. Beattie, Patrick M. Woster, Lyn-Marie Birkholtz, Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities Journal of Medicinal Chemistry. ,vol. 54, pp. 6624- 6633 ,(2011) , 10.1021/JM200463Z
Sylke Müller, Graham H. Coombs, Rolf D. Walter, Targeting polyamines of parasitic protozoa in chemotherapy Trends in Parasitology. ,vol. 17, pp. 242- 249 ,(2001) , 10.1016/S1471-4922(01)01908-0
Kazuei Igarashi, Keiko Kashiwagi, Polyamines: Mysterious Modulators of Cellular Functions Biochemical and Biophysical Research Communications. ,vol. 271, pp. 559- 564 ,(2000) , 10.1006/BBRC.2000.2601