Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent
作者： Li Zheng , Zhanjun Gu , Ying Ma , Guangjin Zhang , Jiannian Yao
DOI: 10.1007/S00775-010-0667-5
关键词:
摘要: Polyoxometalates (POMs) show promising biological activities, but the mechanism of potential therapeutic effects remains to be elucidated at a molecular level. As a step toward the elucidation of the mechanistic pathways governing the bioactivity of POMs, the interaction between Eu-containing decatungstate [EuW 10 O 36] 9−(EuW10) and histone H1 has been studied. Fluorescence/luminescence analysis showed the existence of a strong interaction between EuW10 and histone H1. This interaction has key effects both on the …
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