Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E. coli
作者： Mitsuoki Kawano
DOI: 10.4161/RNA.22757
关键词:
摘要: Toxin-antitoxin (TA) systems are categorized into three classes based on the type of antitoxin. In I TA systems, antitoxin is a small antisense RNA that inhibits translation toxic proteins by binding to corresponding mRNAs. Those were originally identified as plasmid stabilization modules rendering post-segregational killing (PSK) effect host cells. The loci also exist Escherichia coli chromosome but their biological functions less clear. Genetic organization and regulatory elements hok/sok ldr/rdl families very similar toxins predicted contain transmembrane domain, otherwise share no detectable sequence similarity. This review will give an overview E. K-12, especially hok/sok, SOS-inducible symE/symR which regulated divergently overlapping cis-encoded RNAs.
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