How I manage patients with acquired haemophilia A.

摘要: Acquired haemophilia A (AHA) is a potentially life-threatening bleeding disorder occurring in patients without previous personal or family history of bleeding. Development immune-mediated autoantibodies against coagulation factor VIII associated with wide range clinical disorders including pregnancy, autoimmune disorders, malignancy, no apparent disease. There exists great potential for morbidity and mortality related to acute recurrent episodes, making prompt diagnosis treatment necessary. The two primary goals focus on cessation eradication the acquired inhibitor. No randomized trials have been conducted regarding treatment, so expert opinion guides therapeutic intervention. This current report provides profile patient characteristics, an algorithm diagnosis, outlines recommendations based upon guidelines experience. As first-line interventions inhibitor are generally accepted, we will emphasize discussion second-line options.