Perilla frutescens Britton var. frutescens leaves attenuate dextran sulfate sodium-induced acute colitis in mice and lipopolysaccharide-stimulated angiogenic processes in human umbilical vein endothelial cells.
作者： Yuna Lee , Jungjae Lee , Jihyeung Ju
DOI: 10.1007/S10068-019-00711-8
关键词:
摘要: The aim of the current study was to investigate whether leaves Perilla frutescens Britton var. (PL), a frequently consumed vegetable in Korea, attenuate dextran sulfate sodium (DSS)-induced acute colitis mice and lipopolysaccharide (LPS)-stimulated angiogenic processes human umbilical vein endothelial cells (HUVEC). In DSS-treated mice, dietary supplementation with PL mitigated DAI colon shortening. also reduced colonic levels inflammatory mediators, such as interleukin-1β, interleukin-6, monocyte chemoattractant protein-1, macrophage protein-2, leukotriene B4, inducible nitric oxide synthase, cyclooxygenase-2, basic fibroblast growth factor, intercellular adhesion molecule-1 (ICAM-1). Treatment HUVEC ethanol extract attenuated LPS-stimulated increases ICAM-1 levels, adhesion, invasion, tube formation. This suggests that effectively inhibited DSS-induced its anti-angiogenic activities may partially contribute inhibition.
springer.com
sci-hub.se 参考文章(42)
Georges Huez, Véronique Kruys, Tatjana Mijatovic, Véronique Willeaume, Tumor necrosis factor-alpha production induced by viruses and by lipopolysaccharides in macrophages: similarities and differences. Journal of Inflammation. ,vol. 46, pp. 1- 12 ,(1996)
I. D. Pousa, J. Maté, J. P. Gisbert, Angiogenesis in inflammatory bowel disease. European Journal of Clinical Investigation. ,vol. 38, pp. 73- 81 ,(2008) , 10.1111/J.1365-2362.2007.01914.X
Lani Prideaux, Michael A Kamm, Peter P De Cruz, Francis K L Chan, Siew C Ng, Inflammatory bowel disease in Asia: A systematic review Journal of Gastroenterology and Hepatology. ,vol. 27, pp. 1266- 1280 ,(2012) , 10.1111/J.1440-1746.2012.07150.X
Kazuko Shichijo, Mutsumi Matuu, Yuji Ikeda, Shinji Naito, Masahiro Ito, Ichiro Sekine, Clinicopathologic study of dextran sulfate sodium experimental murine colitis Laboratory Investigation. ,vol. 69, pp. 238- 249 ,(1998) , 10.1016/S0021-5198(19)41298-5
Linghua Meng, Yves Lozano, Emile Gaydou, Bin Li, Antioxidant activities of polyphenols extracted from Perilla frutescens varieties. Molecules. ,vol. 14, pp. 133- 140 ,(2008) , 10.3390/MOLECULES14010133
In Jeon, Hyeon Kim, Hyun Kang, Hyun-Seo Lee, Seung Jeong, Sang Kim, Seon Jang, Anti-Inflammatory and Antipruritic Effects of Luteolin from Perilla (P. frutescens L.) Leaves Molecules. ,vol. 19, pp. 6941- 6951 ,(2014) , 10.3390/MOLECULES19066941
BEE-PIAO HUANG, CHUN-HSIANG LIN, YI-CHING CHEN, SHAO-HSUAN KAO, Anti-inflammatory effects of Perilla frutescens leaf extract on lipopolysaccharide-stimulated RAW264.7 cells. Molecular Medicine Reports. ,vol. 10, pp. 1077- 1083 ,(2014) , 10.3892/MMR.2014.2298
Hiroshi Ueda, Masatoshi Yamazaki, Inhibition of tumor necrosis factor-α production by orally administering a perilla leaf extract Bioscience, Biotechnology, and Biochemistry. ,vol. 61, pp. 1292- 1295 ,(1997) , 10.1271/BBB.61.1292
Shuang-sheng Huang, Rong-liang Zheng, Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro Cancer Letters. ,vol. 239, pp. 271- 280 ,(2006) , 10.1016/J.CANLET.2005.08.025
Jane A. Mitchell, Simon Larkin, Timothy J. Williams, Cyclooxygenase-2: Regulation and relevance in inflammation Biochemical Pharmacology. ,vol. 50, pp. 1535- 1542 ,(1995) , 10.1016/0006-2952(95)00212-X