Selenoenzyme activities in selenium- and iodine-deficient sheep.

摘要: This study was conducted to evaluate the effects of single and combined deficiencies selenium iodine on selenoenzyme activities in sheep. Twenty-four male lambs were assigned one four semisynthetic diets: deficient A (Se−I), Se-deficient B (Se−I+), I-deficient C (Se+I−), basal diet D (Se+I+). Thyroid hormones (T3, T4), thyroid stimulating hormone (TSH), inorganic (PII) determined plasma. Selenium glutathione peroxidase activity (GSH-Px) erythrocytes, tissue samples, including thyroid, liver, kidney, brain, taken for analysis. Plasma T3, T4, TSH concentrations similar all groups. Type I deiodinase (ID-I) liver kidney remained unchanged Se or deficiency. In contrast, hepatic ID-I increased by 70% Se-I Thyroidal cystolic GSH-Px (c-GSH-Px) phospholipid (ph-GSH-Px) constant both groups, whereas thyroidal c-GSH-Px (57%) II (ID-II) not detectable cerebrum cerebellum, cerebellum III (ID-III) decreased deficiency deficiencies. The results present support a sensitive interaction between sheep brain. Furthermore, lack activity, presservation antioxidant enzymes, increases indicate that compensatory mechanism(s) works toward retaining plasma T3 levels, mostly de novo synthesis peripheral deiodination T4 Se-