Comparing functional metabolic effects of marginal and sufficient selenium supply in sheep.

摘要: Abstract This study was performed to characterise key data of long-term ovine Se metabolism and work out the best biomarker status. An upgrade from marginal ( Improvement supply strongly increased serum liver concentration within 10 20 days, respectively followed by a plateau. Whereas achievement maximum whole blood Gpx activity reached after 3 months, Gpx3 with high variations. Hepatic during days 100–200, decreasing thereafter. Distinct group differences in cytosolic were evident all organs (except kidney). TrxR Dio1 affected only liver. The Se− sheep showed an ongoing decrease 2 years, whereas remained almost unaffected. High relative Gpx1 mRNA expression Se+ consensual hepatic activity. Relative aGST1 higher sheep. Clinical signs abnormalities routine biochemistry absent. In summary, deprivation nutritional upgrade, serum. Moreover, concentrations reliably reflected days. Whole reacts slowly depending on newly formed erythrocytes restricting its diagnostic use. Vital are deficiency due attenuating antioxidative system. Cellular up-regulation is assumed partially compensate for decreased antioxidant defence loss model appears advantageous studies sub-clinical metabolic effects experimental modifiable supply.