Proteomic investigation of 1,6-dimethoxyhexane testicular toxicity
作者： Guillaume Pelletier , Sheila Masson , Yuan-Ling Wang , Michael G Wade , Susantha Mohottalage
DOI: 10.1016/J.ETAP.2007.04.001
关键词:
摘要: The aliphatic ether 1,6-dimethoxyhexane (DMH) was previously identified as a testicular toxicant. Testis protein extracts from control and DMH-treated rats were subjected to two-dimensional gel electrophoresis for comparison of expression profiles. MALDI-ToF peptide mass fingerprinting differentially expressed proteins resulted in the conclusive identification heat shock-related 70 kDa 2 (HSP70.2), 60 shock protein, mitochondrial precursor (HSP60) disulfide isomerase A3 (ERp60). potential involvement these chemically induced perturbation spermatogenesis their utility biomarkers toxicity are discussed light knowledge currently available literature. © 2007 Elsevier B.V. All rights reserved.
elsevier.com
sci-hub.se 参考文章(51)
Oscar M. Tirado, David M. Selva, Núria Toràn, Carlos A. Suárez-Quian, Michelle Jansen, Donald P. McDonnell, Jaume Reventós, Francina Munell, Increased Expression of Estrogen Receptor β in Pachytene Spermatocytes After Short‐Term Methoxyacetic Acid Administration Journal of Andrology. ,vol. 25, pp. 84- 94 ,(2004) , 10.1002/J.1939-4640.2004.TB02762.X
MEINHARDT, SEITZ, ARSLAN, AUMÜLLER, WEINBAUER, Hormonal regulation and germ cell‐specific expression of heat shock protein 60 (hsp60) in the testis of macaque monkeys (Macaca mulatta and M. fascicularis) International Journal of Andrology. ,vol. 21, pp. 301- 307 ,(2002) , 10.1046/J.1365-2605.1998.00125.X
D. Watanabe, K. Yamada, Y. Nishina, Y. Tajima, U. Koshimizu, A. Nagata, Y. Nishimune, Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development. Journal of Biological Chemistry. ,vol. 269, pp. 7744- 7749 ,(1994) , 10.1016/S0021-9258(17)37349-0
Xue-Sen Zhang, Yah-He Lue, Shu-Hua Guo, Jin-Xiang Yuan, Zhao-Yuan Hu, Chun-Sheng Han, AP Hikim, Ronald S Swerdloff, Christina Wang, Yi-Xun Liu, Expression of HSP105 and HSP60 during germ cell apoptosis in the heat-treated testes of adult cynomolgus monkeys (macaca fascicularis) Frontiers in Bioscience. ,vol. 10, pp. 3110- ,(2005) , 10.2741/1767
Masahito Ikawa, Ikuo Wada, Katsuya Kominami, Daisuke Watanabe, Kiyotaka Toshimori, Yoshitake Nishimune, Masaru Okabe, The putative chaperone calmegin is required for sperm fertility Nature. ,vol. 387, pp. 607- 611 ,(1997) , 10.1038/42484
Raymond Poon, Michael Wade, Victor E Valli, Ih Chu, None, Short-term oral toxicity of butyl ether, ethyl hexyl ether, methyl heptyl ether and 1,6-dimethoxyhexane in male rats and the role of 2-methoxyacetic acid. Toxicology. ,vol. 214, pp. 99- 112 ,(2005) , 10.1016/J.TOX.2005.06.024
Jérôme Govin, Cécile Caron, Emmanuelle Escoffier, Myriam Ferro, Lauriane Kuhn, Sophie Rousseaux, Edward M. Eddy, Jérôme Garin, Saadi Khochbin, Post-meiotic Shifts in HSPA2/HSP70.2 Chaperone Activity during Mouse Spermatogenesis Journal of Biological Chemistry. ,vol. 281, pp. 37888- 37892 ,(2006) , 10.1074/JBC.M608147200
Lars Ellgaard, Eva-Maria Frickel, Calnexin, calreticulin, and ERp57: teammates in glycoprotein folding. Cell Biochemistry and Biophysics. ,vol. 39, pp. 223- 247 ,(2003) , 10.1385/CBB:39:3:223
D. J. Dix, J. W. Allen, B. W. Collins, C. Mori, N. Nakamura, P. Poorman-Allen, E. H. Goulding, E. M. Eddy, Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 3264- 3268 ,(1996) , 10.1073/PNAS.93.8.3264
B. Saradha, P.P. Mathur, Effect of environmental contaminants on male reproduction. Environmental Toxicology and Pharmacology. ,vol. 21, pp. 34- 41 ,(2006) , 10.1016/J.ETAP.2005.06.004