Epstein-Barr Virus Lymphomagenesis and Therapeutic Targets

摘要: The pathogenic role of the Epstein-Barr virus (EBV) has been suggested because it is consistently found in some lymphoproliferative disorders. More than 90% population exposed to virus, usually during childhood, and after initial exposure, survives for lifetime individuals as an episome, expresses a limited set proteins depending on immune status host. variable expression viral known latency pattern with minimal products immunocompetent hosts, but numerous immunocompromised Thus, more that are expressed, targets reaction. Since acknowledged neoplastic process including disorders result from multistep chain events, multiple pathways affected, particular EBV-positive lymphoproliferations, EBV interact abnormally activated context response In this review we analyze structure its interaction well host, discuss possible roles various Finally, potential expressed activation setting specific diagnostic categories identification molecular targets.