Epstein-barr virus latency: LMP2, a regulator or means for Epstein- barr virus persistence?

摘要: Like other herpesviruses, Epstein-Barr virus (EBV) persists in its host through an ability to establish a latent infection that periodically reactivates, producing infectious infects naive hosts. Disease syndromes humans caused by EBV reflect the cell types infects, being primarily of lymphoid or epithelial origin. The most notable disease, mononucleosis, is self-limiting lymphoproliferative disease occurs normal adolescents on primary infection. Children are normally able resolve with few no symptoms. By age 25 individuals seropositive. associated variety hematopoietic cancers such as African Burkitt's lymphoma, Hodgkin's, and adult T-cell leukemia. EBV-associated congenital acquired cellular immune deficiencies. two diseases nasopharyngeal cancer, malignancy endemic southern China, oral hairy leukoplakia, hyperplasia lingual squamous epithelium AIDS patients. Latent membrane protein 2 (LMP2) expressed both latency pathologies. LMP2 may regulate reactivation from interfering B-cell signal transduction processes doing so also provide survival could be important for viral persistence. Current knowledge about function described, defining new class regulators herpesvirus latency.