The Skin: Where Malaria Infection and the Host Immune Response Begin

摘要: Infection by malaria parasites begins with the inoculation of sporozoites into skin host. The early events following sporozoite deposition in dermis are critical for both establishment infection and induction protective immune responses. initial inoculum is generally low, only a small percentage these successfully reach liver grow to next life cycle stage, making this significant bottleneck parasite. Recent studies highlight importance motility host cell traversal dermal exit. Importantly, responses against stages Plasmodium induced dendritic cells lymph node draining site. cellular, molecular, immunological that occur associated nodes topic review.