Effects of raclopride on exploratory locomotor activity, treadmill locomotion, conditioned avoidance behaviour and catalepsy in rats: behavioural profile comparisons between raclopride, haloperidol and preclamol.
作者： Viveka Hillegaart , Sven Ahlenius
DOI: 10.1111/J.1600-0773.1987.TB01525.X
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摘要: : Raclopride, a new potential antipsychotic agent blocking central dopamine (D2) receptors, was found to suppress exploratory locomotor activity, treadmill locomotion and conditioned avoidance response in rats. The threshold dose for effects these test situations about 0.5 mg/kg intraperitoneally. A considerably higher dose, 16 intraperitoneally, needed produce maximal catalepsy. Maximal were obtained within 1–2 hrs the duration of effect 2–8 hrs, depending on situation. behavioural profile raclopride is different from classic haloperidol, (DA) as well partial DA agonist preclamol, which inhibits neurotransmission by activating autoreceptors. Thus, although similar haloperidol other respects, comparatively high doses are catalepsy, indicating less propensity severe extrapyramidal side effects. Raclopride preclamol equipotent suppressing activity. However, more potent than locomotion, behaviour
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