Behavioral profile of raclopride in agonistic encounters between male mice

摘要: Abstract Raclopride is a substituted benzamide with high selectivity as an antagonist of central dopaminergic D 2 receptors and potential antipsychotic effects. In comparison classic DA receptor blocking agent like haloperidol, raclopride displays atypical profile in preclinical tests for extrapyramidal side Antiaggresive properties on agonistic behavior have not yet been fully explored. this work the effects (0.1, 0.3, or 0.6 mg/kg) aggressive motor behaviors male mice were studied. Aggression performed 30 min after injections. Encounters videotaped was evaluated, measuring time spent 11 broad categories behavior. The results show clear antiaggressive effect raclopride, very little impairment some increase exploratory This behavioral similar to one observed other neuroleptics differs somewhat from that found compounds.