Dexmedetomidine selectively suppresses dominant behaviour in aggressive and sociable mice.

摘要: Dexmedetomidine is a highly specific alpha2-adrenoreceptor agonist, which now clinically used to induce sedation in patients the intensive care units. Behavioural effects of dexmedetomidine have been little studied so far. The drug was reported reduce behaviour such as locomotion or measures anxiety aggression animals. aim present study ascertain whether inhibits uniformly with respect particular stimuli situations. Therefore, behavioural were social conflict test male mice (after three weeks individual housing), provides wide spectrum activities two types animals (aggressive and sociable mice) well activity cage. (5-40 microg/kg i.p.) decreased cage this effect fully antagonized by atipamezole, selective alpha2-adrenereceptor antagonist. However, did not during conflict. only significant dose-dependent antiaggressive aggressive reduction investigation ('sociability') mice. Thus, appears inhibit predominantly dominant evoked biologically important stimuli. ability might be utilized for treatment states. Sedation caused can easily disrupted thus may an advantage over benzodiazepines neuroleptics, are indication.