Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice

摘要: Abstract In this study, the effect of Matricaria recutita L. essential oil (MEO) on central nervous system (CNS) mice was investigated using some behavioral methods. Chemical profiling both by GC and GC–MS analyses hydrodistilled M. revealed α-bisabolol oxide A (28%), B (17.1%), ( Z )-β-Farnesene (15.9%) (6.8%) as main components. Changes induced MEO (25, 50 100 mg/kg) reference drug caffeine (25 mg/kg) in spontaneous locomotor activities motor coordinations were activity cage measurements Rota-Rod tests, respectively. Open field, social interaction elevated plus-maze tests applied to assess emotional state animals. Further, tail-suspension test performed for evaluating depression levels mice. As a result, at 100 mg/kg, significantly increased numbers activities, exhibited anxiogenic open decreased immobility times animals tail suspension tests. The falling latencies did not change. This profile similar typical psychostimulant caffeine. exact mechanism action underlying stimulant-like should be clarified with further detailed studies.