Adenosinergic system is involved in development of diazepam tolerance in mice
作者： Joanna Listos , Sylwia Talarek , Sylwia Fidecka
DOI: 10.1016/J.PBB.2009.11.005
关键词:
摘要: Abstract In the present study effect of adenosinergic system on development diazepam tolerance to motor disturbances in mice was investigated. Diazepam obtained by administration at a dose 5.0 mg/kg, s.c. for ten consecutive days. On 1st and 10th day experiment impairments were measured two behavioural tests: rota-rod chimney test. We showed that acute injection produced significant decreased repeated treatment, confirming impairing diazepam. demonstrated adenosine A 1 and/or 2A receptor agonists: CPA (0.025 0.05 mg/kg, i.p.), CGS 21680 (0.1 0.2 mg/kg, NECA (0.005 0.01 mg/kg, i.p.) pretreatment with able attenuate antagonists: DPCPX (1.0 3.0 mg/kg, DMPX (3.0 6.0 mg/kg, caffeine (10.0 20.0 mg/kg, induced opposite effect. The most apparent effects non-selective agonist (NECA) antagonist (caffeine) receptors. conclude plays an important role mechanisms underlying benzodiazepine tolerance.
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