Efforts and Challenges in Engineering the Genetic Code
作者： Xiao Lin , Allen Chi Shing Yu , Ting Fung Chan
DOI: 10.3390/LIFE7010012
关键词:
摘要: This year marks the 48th anniversary of Francis Crick’s seminal work on origin genetic code, in which he first proposed “frozen accident” hypothesis to describe evolutionary selection against changes code that cause devastating global proteome modification. However, numerous efforts have demonstrated viability both natural and artificial variations. Recent advances engineering allow creation synthetic organisms incorporate noncanonical, or even unnatural, amino acids into proteome. Currently, successful is mainly achieved by creating orthogonal aminoacyl-tRNA/synthetase pairs repurpose stop rare codons induce quadruplet codons. In this review, we summarize current progress discuss challenges, understanding, future perspectives regarding
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