Imiquimod Enhances IFN-γ Production and Effector Function of T Cells Infiltrating Human Squamous Cell Carcinomas of the Skin

摘要: Squamous cell carcinomas (SCCs) are sun-induced skin cancers that particularly numerous and aggressive in patients taking T-cell immunosuppressant medications. Imiquimod is a topical immune response modifier Toll-like receptor 7 (TLR7) agonist induces the immunological destruction of SCC other cancers. TLR7 activation by imiquimod has pleiotropic effects on innate cells, but its T cells remain largely uncharacterized. Because tumor formation memory ultimately T-cell-mediated effects, we studied therapy effector infiltrating human SCC. treated with before excision contained dense infiltrates associated apoptosis histological evidence regression. Effector from produced more IFN-γ, granzyme, perforin less IL-10 transforming growth factor-β (TGF-β) than untreated tumors. Treatment normal induced resident reduced production had no effect perforin, or suggesting these latter arise recruitment distinct populations into Thus, stimulates recruiting cutaneous blood inhibiting tonic anti-inflammatory signals within tumor.