Metastasis suppressors in human benign prostate, intraepithelial neoplasia, and invasive cancer: their prospects as therapeutic agents.
作者： Zahraa I. Khamis , Kenneth A. Iczkowski , Qing-Xiang Amy Sang
DOI: 10.1002/MED.20232
关键词:
摘要: Despite advances in diagnosis and treatment of prostate cancer, development metastases remains a major clinical challenge. Research efforts are dedicated to overcome this problem by understanding the molecular basis transition from benign cells prostatic intraepithelial neoplasia (PIN), localized carcinoma, metastatic cancer. Identification proteins that inhibit dissemination cancer will provide new perspectives define novel therapeutics. Development antimetastatic drugs trigger or mimic effect metastasis suppressors represents therapeutic approaches improve patient survival. This review focuses on different biochemical cellular functions known play role carcinogenesis progression. Ten putative implicated discussed. CD44s is decreased both PIN cancer; Drg-1, E-cadherin, KAI-1, RKIP, SSeCKS show similar expression between epithelia PIN, but downregulated invasive whereas, maspin, MKK4, Nm23 PTEN upregulated Moreover, potential microRNA progression, distribution localization suppressors, their mechanism action, invasion metastasis, use as therapeutics addressed.
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