Myocardial functional preservation during ischemia: Influence of beta blocking agents
作者： Philip M. Toleikis , Charles W. Tomlinson
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摘要: To determine whether prior acute Beta blockade protects the heart against deleterious effects of normothermic low flow global ischemia on myocardial function, aortic pressure, developed dP/dtmax and end diastolic pressure were monitored in isolated perfused rabbit hearts to, during following 30 60 min ischemia, which either Krebs-Henseleit (control) or blocking agents, Bevantolol (cardioselective) Propranolol (non-selective) through heart. Control made ischemic for then reperfused had significantly elevated (p 0.05), while was .05). Comparison indices from under with controls showed that recovery, treated group reduced .05) (K-H). We conclude short periods function but protective effect is diminished relative to treatments prolonged ischemia. The data indicates beneficial reducing induced damage occurs early conditions such as would be present setting infarction.
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