5-hydroxymethylcytosine-mediated DNA demethylation in stem cells and development.
作者： Wenjia Sun , Minxin Guan , Xuekun Li
关键词:
摘要: The pursuit of DNA demethylation has a colorful history, but it was not until 2009 that the stars this story, Ten-eleven-translocation (Tet) family proteins, were really identified. Tet proteins convert 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which can be further oxidized 5-formylcytosine and 5-cyboxycytosine by achieve demethylation. Recent studies have revealed 5hmC-mediated play essential roles in diverse biological processes, including development diseases. Here, we review recent discoveries context stem cells development.
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