Conjugation of chemical carcinogens by primary cultures of human hepatocytes
作者： D. K. Monteith , G. Michalopoulos , S. C. Strom
DOI: 10.3109/00498259009046890
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摘要: 1. The conjugation of benzo[a]pyrene (BP) and 2-acetylaminofluorene (AAF) was investigated in primary cultures human hepatocytes. Human hepatocytes conjugated 12.5-63% the BP 1.7-52% AAF to sulphates glucuronides over a thousand-fold concentration range. 2. is from non-detectable levels 50%, 30%. major metabolites are highly polar metabolites. 3. 1.5 51% 0.2 12%. C-hydroxylated were more than N-hydroxy aminofluorene
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