Formation of Propionibacterium acnes biofilms on orthopaedic biomaterials and their susceptibility to antimicrobials

摘要: Failure to treat and eradicate prosthetic hip infection with systemic antibiotic regimens is usually due the fact that associated biofilm formation bacterial cells growing within a exhibit increased resistance antimicrobial agents. In this in vitro study, we investigated susceptibility of Propionibacterium acnes Staphylococcus spp. isolates biofilms on polymethylmethacrylate (PMMA) bone cement range antibiotics. All P. mode growth demonstrated considerably greater cefamandole, ciprofloxacin vancomycin. contrast, only four eight an increase gentamicin. ten exhibited large increases gentamicin cefamandole also exhibiting However, three ciprofloxacin. Biofilms were formed different titanium alloys PMMA using acnes, epidermidis aureus strains determine if underlying biomaterial surface had effect bacteria biofilms. Although differences rate at which adhered biomaterials apparent, no between observed. light these results, it important efficacy other antibiotics against orthopaedic be determined ensure optimal treatment implant infection.