Using clinically acquired MRI to construct age‐specific ADC atlases: Quantifying spatiotemporal ADC changes from birth to 6‐year old

摘要: Diffusion imaging is critical for detecting acute brain injury. However, normal apparent diffusion coefficient (ADC) maps change rapidly in early childhood, making abnormality detection difficult. In this article, we explored clinical PACS and electronic healthcare records (EHR) to create age-specific ADC atlases radiology reference. Using the EHR three rounds of multiexpert reviews, found from 201 children 0-6 years age scanned between 2006 2013 who had MRIs with no reported abnormalities evaluations 2+ later. These images were grouped 10 bins, densely sampling first 1 year life (5 including neonates 4 quarters) representing 1-6 range (an bin per year). Unbiased group-wise registration was used construct bins. We quantify (a) cross-sectional normative variations; (b) spatiotemporal heterogeneous changes; (c) volumetric changes. The quantified whole-brain region-wise values compared those age-matched individual subjects our study multiple existing independent studies. significance that have shown clinically acquired can be atlases. their kind quantitatively characterize changes myelination-related water 6 life. voxel-wise variations provide standard references assist radiologists toward more objective interpretation images. Our are available at https://www.nitrc.org/projects/mgh_adcatlases. Hum Brain Mapp 38:3052-3068, 2017. © 2017 Wiley Periodicals, Inc.