Dermatopolymyositis and other connective tissue diseases: a review of 105 cases.

摘要: Of 105 cases seen over 12 years with mean 4 followup, there were 69 polymyositis (PM) and 36 dermatomyositis (DM). in 43 this complicated another connective tissue disease (CTD). Primary PM had onset a decade later than others most severe myopathy occurred DM. Earliest symptoms polyarthritis Raynaud's phenomenon frequent sicca syndrome (51%). The less universal prevalence of elevated muscle enzymes (68%), myopathic electromyography (86%). abnormal biopsy (78%) emphasizes the need for complete evaluation all cases. Improvement 69% overall, including 23 given no therapy or low dose corticosteroids 59% remainder who received high added cytotoxics one-quarter. Outcome was worse older patients those where weakness exceeded months before diagnosis. Eight 19 deaths due to myositis its which also caused considerable morbidity. Malignancy 16 temporally related half these