Autonomic dysfunction and neuropeptide Y in fibromyalgia.

摘要: Objective. Fibromyalgia (FM) is a syndrome associated with widespread pain and various other signs symptoms. Several of these multisystem features could be explained on the basis autonomic nervous system (ANS) dysfunction. Methods. The aim present study was to evaluate ANS dysfunction in FM based time-domain heart rate variability (HRV) analysis serum neuropeptide Y (NPY) levels 51 patients FM, 25 systemic sclerosis (SSc), 15 healthy controls (NHS). Results. Compared SSc NHS groups, group had significantly higher NPY levels, subgroup subjected HRV (25/51 patients, 49%), certain indices were reduced. In this subgroup, correlated SDANN index NN50, but neither or parameters showed any significant correlation clinical aspects FM. Conclusion. These findings suggest that are crucial elements pathophysiology Additional studies necessary define complex roles played by modulating immunological functions different diseases.