Angiogenic and MMPs modulatory effects of icariin improved cutaneous wound healing in rats.
作者： Wangkheirakpam Ramdas Singh , Hijam Shila Devi , Sanjay Kumawat , Abdul Sadam , Aneesha V. Appukuttan
DOI: 10.1016/J.EJPHAR.2019.172466
关键词:
摘要: Abstract Icariin is a flavonoid from plant belonging to the genus Epimedium, commonly known as Horny goat weed or Yin Yang Huo. The compound possesses multiple biological activities which are associated with modulation of many signalling pathways, like NF-κB, Erk-p38-JNK, and release various cytokines growth factors. present study determined wound healing potential icariin in male Wistar rats. ointment (0%, 0.004%, 0.02%, 0.1% 0.5%), was applied daily (b.i.d.) for 14 days on ≈ 400 mm2 cutaneous different groups On day post-wounding, 0.5% treatment significantly (P
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