CD8+CD28− T Regulatory Lymphocytes Inhibiting T Cell Proliferative and Cytotoxic Functions Infiltrate Human Cancers

摘要: Tumor growth is allowed by its ability to escape immune system surveillance. An important role in determining tumor evasion from control might be played tumor-infiltrating regulatory lymphocytes. This study was aimed at characterizing phenotype and function of CD8+ CD28- T cells infiltrating human cancer. Lymphocytes primitive lesion and/or satellite lymph node a series 42 cancers were phenotypically studied functionally analyzed suppressor assays. The unprecedented observation made that lymphocytes are almost constantly present functional tumors, being able inhibit both cell proliferation cytotoxicity. CD4+ CD25+ associate with so the immunosuppressive activity subsets, altogether considered, may become predominant. infiltration seems related, metastatic but not metastasis-free nodes; it likely depends on situ generation (via cytokine production) recruitment periphery chemokine secretion). Collectively, these results have pathogenic relevance implication for immunotherapy