Constitutive expression of G-CSF and GM-CSF in human skin carcinoma cells with functional consequence for tumor progression

摘要: Tumor progression is characterized by an increasing escape of tumor cells from the growth control their microenvironment, often caused aberrant expression factors. In human skin carcinoma model system, based on HaCaT keratinocyte line, to high-grade malignant associated with constitutive and secretion hematopoietic factors G-CSF GM-CSF in vitro vivo. All variants express receptors at levels comparable normal keratinocytes. Consequently, they exhibit a stimulation cell proliferation migration culture when treated these Moreover, both were strongly inhibited neutralizing antibodies GM-CSF, respectively. This demonstrates functional role through autocrine mechanism implies significance light use adjuvant therapy, our data, as well those disussed for head-and-neck tumors gliomas, warrant careful re-evaluation clinical application Int. J. Cancer 83:780–789, 1999. © 1999 Wiley-Liss, Inc.