Protein Tyrosine Kinase Growth Factor Receptors and their Ligands in Development, Differentiation, and Cancer

摘要: Publisher Summary The protein tyrosine kinases (PTKs) are a thematic family––built around highly conserved domain capable of phosphorylating substrates on residues. Members this family made up as mosaic sensory, regulatory, and effector domains. the receptor (RTK) hold number structural features, such an extracellular ligand-binding domain, single transmembrane kinase one regulatory which serves to reign in catalytic activity PTK domain. This chapter discusses structure RTK, its developmental mutants, tumorigenesis. expression patterns many human, murine, Drosophila RTKs have been determined by Northern analysis mRNAs from adult tissues. detected at elevated levels particular types tumor. may be overexpressed or inappropriately expressed ligand-independent activated form transform cells. also reviews several aspects oncogenicity members RTK signal transduction pathways downstream receptor. alterations associated with acquisition class proteins focused chapter.