A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
作者： William Matthews , Craig T. Jordan , Gordon W. Wiegand , Drew Pardoll , Ihor R. Lemischka
DOI: 10.1016/0092-8674(91)90010-V
关键词:
摘要: To elucidate the molecular biology of hematopoietic stem cell, we have begun to isolate genes from murine cell populations enriched in activity. One such cDNA encodes a novel receptor tyrosine kinase, designated fetal liver kinase-2 or flk-2, which is related W locus gene product c-kit. Expression analyses suggest an extremely restricted distribution flk-2. It expressed for cells and primitive uncommitted progenitors, absent containing more mature cells. Therefore, this may be key signal transducing component totipotent its immediate self-renewing progeny.
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