Efferent intestinal lymph protein responses in nematode-resistant, -resilient and -susceptible lambs under challenge with Trichostrongylus colubriformis
作者： J.J. Bond , A. Pernthaner , K. Zhang , S.M. Rosanowski , S. Clerens
DOI: 10.1016/J.JPROT.2014.07.017
关键词:
摘要: Abstract The mechanisms underlying resistance to challenge by gastrointestinal nematode parasites in sheep are complex. Using DIGE, we profiled ovine lymph proteins lambs with host (R), resilience (Ri) or susceptibility (S) a daily trickle the Trichostrongylus colubriformis. Efferent intestinal was collected prior infection (day 1) and on days 5 10 post-infection. Eight identified LC-MS/MS, showed differences relating genotype. Of these, Serpin A3-3 A3-7 have not been reported previously proteome. Three acute phase significant interactions between breeding line parasite challenge, including complement C3β, C3α haptoglobin (Hp) β. In R significantly up regulated (P Biological Significance Breeding lines of infections provide an experimental model examine biological ability some expel worms remain healthy without use anthelmintic. proteomics expression R, Ri S lambs. results will assist development alternative control strategies manage livestock.
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