摘要: Chronic airways infection is associated with the greatest morbidity and mortality of patients cystic fibrosis (CF). The CF become infected early in life once established, difficult, if not impossible, to eradicate, Pseudomonas aeruginosa becoming predominant organism over time. Aerosol antibiotics have been used successfully for suppression chronic but are being investigated even earlier use, such as treatment first infection. This review will address important factors choice an antibiotic infection, potential advantages aerosol antibiotics, outcomes that could be considered assessment aerosolized disease. Pediatr Pulmonol. 2008; 43:S29–S34. © 2008 Wiley-Liss, Inc.
sci-hub.se 参考文章(33)
Allan Weber, Robin L. Davis, Arnold L. Smith, Paul M. Mendelman, Bonnie Ramsey, Jack Levy, Aminoglycoside penetration, inactivation, and efficacy in cystic fibrosis sputum The American review of respiratory disease. ,vol. 132, pp. 761- 765 ,(1985) , 10.1164/ARRD.1985.132.4.761
Timothy D. Murphy, Ran D. Anbar, Lucille A. Lester, Samya Z. Nasr, Bruce Nickerson, Donald R. VanDevanter, Andrew A. Colin, Treatment with tobramycin solution for inhalation reduces hospitalizations in young CF subjects with mild lung disease Pediatric Pulmonology. ,vol. 38, pp. 314- 320 ,(2004) , 10.1002/PPUL.20097
Alan S. Brody, Heidi Sucharew, Jonathan D. Campbell, Steven P. Millard, Paul L. Molina, Jeffrey S. Klein, Joanne Quan, Computed tomography correlates with pulmonary exacerbations in children with cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. ,vol. 172, pp. 1128- 1132 ,(2005) , 10.1164/RCCM.200407-989OC
M W Konstan, K A Hilliard, T M Norvell, M Berger, Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. American Journal of Respiratory and Critical Care Medicine. ,vol. 150, pp. 448- 454 ,(1994) , 10.1164/AJRCCM.150.2.8049828
Alexandra L. Quittner, Anne Buu, Effects of tobramycin solution for inhalation on global ratings of quality of life in patients with cystic fibrosis and Pseudomonas aeruginosa infection. Pediatric Pulmonology. ,vol. 33, pp. 269- 276 ,(2002) , 10.1002/PPUL.10074
Margaret Rosenfeld, Julia Emerson, Judy Williams-Warren, Margaret Pepe, Arnold Smith, A.Bruce Montgomery, Bonnie Ramsey, Defining a pulmonary exacerbation in cystic fibrosis The Journal of Pediatrics. ,vol. 139, pp. 359- 365 ,(2001) , 10.1067/MPD.2001.117288
Warren E. Regelmann, Greg R. Elliott, Warren J. Warwick, C. C. Clawson, Reduction of sputum Pseudomonas aeruginosa density by antibiotics improves lung function in cystic fibrosis more than do bronchodilators and chest physiotherapy alone. The American review of respiratory disease. ,vol. 141, pp. 914- 921 ,(1990) , 10.1164/AJRCCM/141.4_PT_1.914
Carla Colombo, Diana Costantini, Alessia Rocchi, Lisa Cariani, Maria Laura Garlaschi, Silvia Tirelli, Giliola Calori, Elena Copreni, Massimo Conese, Cytokine levels in sputum of cystic fibrosis patients before and after antibiotic therapy. Pediatric Pulmonology. ,vol. 40, pp. 15- 21 ,(2005) , 10.1002/PPUL.20237
Karen S. McCoy, Compounded colistimethate as possible cause of fatal acute respiratory distress syndrome. The New England Journal of Medicine. ,vol. 357, pp. 2310- 2311 ,(2007) , 10.1056/NEJMC071717
F. J. McLaughlin, W. J. Matthews, D. J. Strieder, B. Sullivan, A. Taneja, P. Murphy, D. A. Goldmann, Clinical and Bacteriological Responses to Three Antibiotic Regimens for Acute Exacerbations of Cystic Fibrosis: Tlcarcillln-Tobramycin, Azlocillin-Tobramycin, and Azlocillin-Placebo The Journal of Infectious Diseases. ,vol. 147, pp. 559- 567 ,(1983) , 10.1093/INFDIS/147.3.559