Características funcionais pulmonares e uso de broncodilatador em pacientes com fibrose cística

摘要: OBJECTIVE: To analyze pulmonary function parameters and pharmacodynamic response to a bronchodilator, as well the prescription of bronchodilators, in cystic fibrosis (CF) patients. METHODS: This was retrospective cohort study involving patients 6-18 years age, diagnosed with CF, followed at referral center between 2008 2010. We evaluated only those who were able perform tests (PFTs). analyzed FVC, FEV1, FEF25-75%, expressed percentages predicted values, prior after bronchodilator (pre-BD post-BD, respectively), 312 PFTs. Repeated measures ANOVA multiple comparisons used. RESULTS: The included 56 patients, divided into two groups: whose PFT results spanned 2008-2010 period (n = 37); 2009-2010 19). In group, there significant reductions post-BD FEV1 2010 (p 0.028) 2009 0.036), also case for pre-BD FEF25-75% all (2008 vs. 2009; 2010; 2010). no differences any variables studied. Among PFTs, responses occurred 24 (7.7%), which from whom had been prescribed during period. CONCLUSIONS: CF studied, loss function, indicating progressive lung disease, over time. changes greater than other variables, suggests initial involvement small airways.