Use of CTLA4-Ig in combination with conventional immunosuppressive agents to prolong allograft survival
作者： Douglas A. Hale , Rita Gottschalk , Takashi Maki , Anthony P. Monaco
DOI: 10.1097/00007890-199709270-00018
关键词:
摘要: Background The objective of our study was to determine the effectiveness CTLA4-Ig, a novel immunosuppressive agent, in augmenting allograft survival when combined with either cyclosporine, sirolimus, donor-specific bone marrow alone (BM), or conjunction antilymphocyte serum (ALS). Methods Full-thickness skin allografts were used C3H B6AF1 (class I mismatch) and AKR C57BL/6 (complete models. Groups mice (n=6-14) treated various combinations following treatment protocols: murine L-6 control Ig, ALS, ALS/BM. Results In class mismatch model, Ig had no effect whereas use CTLA4-Ig resulted doubling median graft compared controls. addition sirolimus cyclosporine increased over that achieved alone. demonstrated efficacy combination BM, clearly less effective complete model. Conclusion These data suggest may be clinically but offers additional without marrow.
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